Chimpanzee adenoviral vectors as vaccines for outbreak pathogens
نویسندگان
چکیده
منابع مشابه
Chimpanzee adenoviral vectors as vaccines for outbreak pathogens
The 2014-15 Ebola outbreak in West Africa highlighted the potential for large disease outbreaks caused by emerging pathogens and has generated considerable focus on preparedness for future epidemics. Here we discuss drivers, strategies and practical considerations for developing vaccines against outbreak pathogens. Chimpanzee adenoviral (ChAd) vectors have been developed as vaccine candidates f...
متن کاملSynanthropic Ants as Vectors of Pathogens in Hospitals of Iran
Background: Synanthropic ants can transmit pathogens especially in hospital environments, but this fact had not been confirmed in Palaearctic region. This is the first study on confirming this ability of ants in this region. Methods: Three hospitals of Bandar Abbas, Iran have been selected for monthly sampling of ants in their various wards. The main processe...
متن کاملAdenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines.
CD8(+) T cell-numbers rapidly expand and then contract after exposure to their cognate antigen. Here we show that the sustained frequencies of transgene product-specific CD8(+) T cells elicited by replication-defective adenovirus vectors are linked to persistence of low levels of transcriptionally active adenovirus vector genomes at the site of inoculation, in liver, and lymphatic tissues. Cont...
متن کاملHeteroptera as Vectors of Plant Pathogens
RESUMO A habilidade de insetos picadores-sugadores em transmitir doenças para as plantas está intimamente relacionada ao modo de alimentação e ao tecido alvo. Os percevejos são considerados de importância econômica mínima como vetores de patógenos de plantas, embora tenham comportamento alimentar semelhante aos homópteros. Os modos de alimentação em Heteroptera incluem “dilaceração e bombeament...
متن کاملReplicon RNA Viral Vectors as Vaccines
Single-stranded RNA viruses of both positive and negative polarity have been used as vectors for vaccine development. In this context, alphaviruses, flaviviruses, measles virus and rhabdoviruses have been engineered for expression of surface protein genes and antigens. Administration of replicon RNA vectors has resulted in strong immune responses and generation of neutralizing antibodies in var...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Human Vaccines & Immunotherapeutics
سال: 2017
ISSN: 2164-5515,2164-554X
DOI: 10.1080/21645515.2017.1383575